Sigma Symposium Radboud Universiteit Nijmegen April 16th 2014 
Sigma Symposium 2013: Size Matters - Applications of Nanotechnology Sigma Symposium 2014: Size Matters - Applications of NanotechnologySigma Symposium 2014: Size Matters - Applications of Nanotechnology


The following lecturers have agreed to speak on our symposium:

- Dr. R. van der Meel, Nanobullets: Ligand-targeted nanomedicines for cancer treatment

Dr. B. Hulsken, Scanning Tunneling Microscopy (STM) in liquids

Dr. B. Sciacca, Core-shell nanowires for photovoltaics

- Dr. med. D. Wenzel, Improvement of vascular function by magnetic nanoparticle (MNP)-assisted gene and endothelial cell transfer in vessels

- Prof. Dr. J.C.T. Eijkel, Blue energy: Microfluidic energy conversion


Master of Ceremony: Prof. Dr. Ir. Jan van Hest


About our master of ceremony and the lecturers:

Jan van Hest

Radboud University Nijmegen

Curriculum Vitae

Jan. C. M. van Hest (1968) conducted his doctoral research on molecular architectures based on dendrimers at the Eindhoven University of Technology under supervision of Prof. Bert Meijer, for which the Ph.D. title was granted in 1996. As a postdoctoral researcher he investigated the possibilities of protein engineering for the preparation of materials under supervision of Prof. D. A. Tirrell, at the University of Massachusetts in Amherst. In 1997 he joined the chemical company DSM, where he worked as research scientist and later on as group leader on the development of innovative material concepts. In 2000 he was appointed as a full professor in bio-organic chemistry at the Radboud University Nijmegen. His current research efforts are aimed at developing bio-inspired materials and processes in order to combine the functionality of biological systems with the exibility and robustness of synthetic structures. Jan van Hest is a VICI recipient and was a member of The Young Academy of the Royal Netherlands Academy of Arts and Sciences from 2005 to 2010.  He is a member of the research team that was awarded a gravity program grant for Functional Molecular Systems in 2012.

Roy van der Meel

University Medical Centre Utrecht

Curriculum Vitae

Roy van der Meel (1984) obtained a Bsc. in Biomedical Sciences at Utrecht University in 2006. He continued with the Master’s program Drug Innovation during which he was involved in several research projects. In 2007 he worked on the development of targeted lipoplexes for inhibition of angiogenesis under the supervision of dr. Sabrina Oliveira and dr. Raymond M. Schiffelers at the department of Pharmaceutics at Utrecht University. In 2008 he spent one year at the Cancer Biology and Therapeutics Lab at the UCD Conway Institute in Dublin, Ireland. There he focused on screening Rho GTPases as therapeutic targets for inhibition of angiogenesis under the supervision of dr. Annette T. Byrne and prof.dr. William M. Gallagher. After graduating cum laude in 2009, he returned to the department of Pharmaceutics to start his PhD project under the supervision of prof.dr. Gert Storm, prof.dr. Wim E. Hennink, dr. Robbert J. Kok and dr. Raymond M. Schiffelers. During his work as a PhD candidate, Roy explored several targeted (nanomedicine) strategies to inhibit tumor growth and angiogenesis for the treatment of cancer. He obtained his PhD in 2013. Roy currently holds a post-doc position at the Laboratory of Clinical Chemistry and Haematology of the University Medical Center Utrecht where he investigates the application of extracellular vesicles as biomarkers for clinical diagnostics. 

Lecture: "Nanobullets: Ligand-targeted nanomedicines for cancer treatment"


Important Publications

Article 1    Article 2    Article 3

Bas Hulsken

Philips Eindhoven

Bas Hulsken (1977) received both his MSc. in Physics and his MSc. in Natural Sciences in 2001 from the University of Nijmegen. For his double-degree masters research project, under the supervision of Prof. Dr. Herman van Kempen, he performed a Scanning Tunnelling Microscopy (STM) investigation into Wächtershäuser's iron-sulphur word theory on the origin of life.

In 2001 he started his PhD study under the supervision of Prof. Dr. Sylvia Speller building on and extending the methods for performing STM at the solid-liquid interface developed during his masters project. The liquid-cell STM pioneered during his masters was now applied to a broader study of both mechanical and chemical modification of solid-liquid interfaces, and the investigation of the physics and chemistry of catalytic surfaces.

After his completing his PhD research in 2006, he started to work for Philips corporate research, on the development of novel microscopy applications for the healthcare domain. He is currently the technology director of Philips Digital Pathology Solutions, which is bringing high performance digital microscopy and work-flow solutions to the pathology lab in hospitals over the world.

Lecture: "Scanning Tunnelling Microscopy (STM) in liquids"


Important publications

Article 1    Article 2    Article 3

Beniamino Sciacca

FOM Institute AMOLF

Curriculum Vitae

Dr. Beniamino Sciacca received his BSc. degree in biomedical engineering from 'Politecnico di Torino', Italy, in 2004, discussing the thesis "Electrical characterization of microelectrode arrays". In 2006 he received his MSc degree in biomedical engineering from 'Politecnico di Torino' and 'Politecnico di Milano', under a double-degree project, discussing a research thesis entitled "A molecular mechanics study of the interaction between microcantilever and DNA fragments". In 2007 he began his PhD study under the supervision of Prof. F. Geobaldo, in the Department of Materials Science and Chemical Engineering at "Politecnico di Torino", working on porous silicon photonic nanostructures for biosensing devices, and obtained the PhD in 2010. During his PhD he has been visiting student for six months in Prof. M. Sailor group, at the University of California San Diego (UCSD), USA, and for three months in Dr. F. Cunin group, at the "Institut Charles Gerhardt Montpellier, France. In March 2011 he joined Prof. Tanya Monro's research group at the Institute for Photonics & Advanced Sensing (IPAS) as a postdoctoral associate, working on SPR biosensors for early gastric cancer detection. In March 2013 he joined the Nanoscale Solar Cells group led by Dr. Erik Garnett at FOM Institute AMOLF (NL), working as a postdoc on the synthesis and characterization of core-shell nanowires for photovoltaics. 

Lecture: "Core-shell nanowires for photovoltaics"


Important publications

Article 1    Article 2    Article 3

Daniela Wenzel

University of Bonn

Curriculum Vitae


2005 - MD thesis at the Institute for Neurophysiology, University of Cologne, Germany Endostatin induces vasorelaxation and anti-angiogenic effects via differential regulation of the NO 
2004 - Graduation and “Approbation” (license to practice medicine), University of Cologne, Germany 
1997-2004 - Studies of Medicine and Physics at the University of Cologne, Germany, the University of Nottingham, UK and the Universitá di Bologna, Italy


2012 - Specialist examination in Physiology at the Medical Council North Rhine, Germany
Since 2010 - Junior Research Group Leader, “Magnetic nanoparticles (MNPs)- endothelial cell replacement in injured vessels” funded by the Ministry of Innovation, Science and Research of the federal state of North Rhine-Westphalia (NRW), University of Bonn
2005-2010 - Postdoctoral scientist at the Institute of Physiology I at the University of Bonn (Prof. Dr. B. Fleischmann)

Prizes and awards

2014 - René Baumgart Foundation Award
2013 - “Top paper published in Hypertension Award, Basic Science Category“, High Blood Pressure Research Council, American Heart Association
2010 - BONFOR prize of the University of Bonn for junior research group
1997 - Fellowship of the German National Merit Foundation

Lecture: "Improvement of vascular function by magnetic nanoparticle (MNP)-assisted gene and endothelial cell transfer in vessels"

Jan Eijkel

Twente University

Curriculum Vitae

Jan Eijkel was born in Amsterdam in 1955. He studied pharmacy at the University of Amsterdam and then worked as a public pharmacist while studying theology at the University of Utrecht. He obtained his Ph.D. degree in 1995 at the University of Twente with prof.dr. Piet Bergveld on potentiometric protein detection using ISFETs. He then became postdoc at Imperial College London with prof. Andreas Manz, developing a microplasma-based gas sensor and a circular liquid chromatography microdevice. In February 2003 he was appointed at the BIOS/Lab-on-a-Chip group of the MESA+ Institute for Nanotechnology at the University of Twente as a postdoc in the area of nanofluidics research. Since 2010 he is full professor Nanofluidics for Lab on a Chip Applications at Twente University.

The focus of his research is on the investigation of physicochemical phenomena in micro- and nanofluidic systems, and their applications. These investigations include capillary filling and drying, osmosis, o/w two-phase flow, transport and separation of ions and DNA and fluidic energy generation. His group has made a number of original and significant contributions to the field, such as the observation and analysis of corner flow in two-phase nanofluidic systems, the electrokinetic generation of large negative pressures in nanochannels, the occurrence of cross-wall transport due to wall permeability in nanofluidic systems, the control of the chemistry in micro- and nanochannels by gate-induced proton release from the channel walls, the observation of a field-dependent mobility of DNA in nanochannels, the formation of 3D microemulsion crystals in nano/microchannel devices and most recently the development of high-efficiency ballistic energy conversion using a microjet. Under his guidance novel devices were developed, such as a microfluidic electrostatic generator, a Fabry-Pérot interferometer with embedded nanochannels, all-polyimide nanochannels, and a field-effect based nanofluidic titrator. This research five times made the cover of the leading “Lab on a Chip” journal. Jan Eijkel is editor of the Microfluidics and Nanofluidics journal and regularly invited for international conferences. In 2009 he was awarded a TOP research grant of the Dutch Funding organisation NOW together with Albert van den Berg for work on “Energy from streaming potential using nanotechnology”.

Lecture: "Blue energy: Microfluidic energy conversion"